The current study aims to investigate all forms of human rights violence against all women and girls in public and private spheres including trafficking and sexual and other types of exploitation, based on cultural diversity. For this purpose, study has followed the review of already published studies with implication of cultural relativism and Human Rights and Diversity. Extreme cultural relativism provoked one’s intention to support his culture and contributed to discrimination against the others. Analysis shows that the major challenge to the women of Venezuela are economic, and social and cultural issues. The only solution of this problem is to strengthen the legislative structure and judicial system of the Venezuela, and assurance to implementation of Universal Human Rights Conventions through involvement of international organizations. Moreover, the women and men should be provided equal opportunities of earning, no matter to which culture do they belong.