Chronic kidney disease-associated pruritus (CKD-aP), formerly known as the uremic pruritus, is commonly observed in the patients with the hemodialysis. This study aimed to determine the prevalence of the Ckd-aP and to associate it with depression in hemodialysis patients. A multicenter cross-sectional study was conducted on the patients of CKD-aP Khyber Pakhtunkhwa, from March 2021 to March 2022. This research was conducted at multiple hospitals in the Khyber Pakhtunkhwa (different hospitals such as Hayat Abad Medical Complex, Zia Medical complex, Irfan General Hospital, and others). The sample size for this research was 1000, of which 700 were confirmed patients with the CKD-aP. Research shows that the prevalence of CKD-aP is higher in males than in females. This disease creates a negative impact on mental health and causes a range of depressive disorders, among diseased persons.