Scandic Journal of Advanced Research and Reviews
ISSN 2703-965X

International Journal with High Impact Factor for fast publication of Research and Review articles

Nedre prinsdal vei 143, 1263 Oslo, Norway

Interleukin-38 Level and Polymorphism (Rs 6743376) Associated with Rheumatoid Arthritis

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Vol. 2, Issue 6, MAY 2022

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Mohammed Issa Ibrahim Islemeh ¹Bushra Mubarak ² and Amina Elahi³

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Rheumatoid arthritis (RA) is a multifaceted autoimmune disorder defined by persistent inflammation and joint damage. This study explores the intricate relationship between RA severity and interleukin-38 (IL-38), a cytokine having anti-inflammatory properties. Our research reveals a strong connection between elevated plasma IL-38 levels and the severity of RA, indicating IL-38’s crucial role in modulating inflammation. Elevated ESR levels in RA patients highlight active inflammation. Genetic analysis shows specific IL-38 polymorphisms associated with RA susceptibility, emphasizing the disease’s genetic basis. These findings position IL-38 as a promising indicator for assessing rheumatoid arthritis RA severity by providing valuable insights into its genetic mechanisms. Understanding IL-38-related pathways could revolutionize RA management strategies.


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